A series of novel 5-(2-Amino-phenyl)-3H-[1, 3, 4] oxadiazole-2-thione was prepared by reacting Methyl anthranilate and hydrazine hydrate to give 2-Amino-benzoic acid hydrazide which reacts with CS2 / KOH to give 5-(2-Amino-phenyl)-3H-[1, 3, 4] oxadiazole-2-thione Compounds were synthesized by conventional synthesis method The purity of all synthesized compounds was determined by thin layer chromatography .All synthesized compounds by IR spectroscopy confirmed the functional groups .NMR indicated that all the chemical shift values were found in range. Mass confirms molecular weight of synthesized compound Oxadiazole nucleus is continuously drawing interest for development of newer drug moiety. Due to its wide range of activities viz. anticancer, antibacterial, antifungal, antimalarial, anticonvulsant anti-inflammatory etc. the steady research is going on in oxadiazole nucleus. Oxadiazole type of heterocyclic compounds contains oxygen and two nitrogen atoms
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